Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC040
Sex MALE
Dominant hand LEFT
Test administered by neuromedic@manusdevices.net
Test date and time 2022-08-09 13:18
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment tbl Madopar a 250mg 3x1/2 caps Madopar HBS a 125mg 1 uvece Older patient

Overall Assessment

PD

Subject performance similar to PD population (recommend review of report details)

Clinical context

In the clinical reference population, 40 individuals with a value less than 0.73 were subsequently diagnosed with PD. That is, 95.24% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.73 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 5, 'TN': 6, 'TP': 37, 'FP': 24}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 1, 'TN': 2, 'TP': 41, 'FP': 28}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 28, 'TN': 23, 'TP': 14, 'FP': 7}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 25, 'TN': 17, 'TP': 17, 'FP': 13}

Test Battery Details

Circle

numCircles 10
timePerCircleMean 16.856
timePerCircleCoV 0.647501
timePerCircleSlope -0.170686
meanError 1.23018
tremorFreq 5.56641
tremorRelPower 25.0995
tremorGyroAmpMean 0.0182401
tremorGyroAmpSlope 0.00220892
tremorGyroAmpCoV 0.378821
tremorCoordAmpMean 0.0247058
tremorCoordAmpSlope 0.00393197
tremorCoordAmpCoV 0.246863
tremorAccAmpMean 0.0434654
tremorAccAmpSlope 0.000736667
tremorAccAmpCoV 0.118937
tremorPcRelVar 0.599048
tremorPcX 0.261529
tremorPcY -0.965196

Circle Segment 1

Duration 45.24 s, Accuracy Estimate 1.414 (lower is better)

Circle Segment 2

Duration 23.92 s, Accuracy Estimate 0.801 (lower is better)

Circle Segment 3

Duration 16.72 s, Accuracy Estimate 1.033 (lower is better)

Circle Segment 4

Duration 15.48 s, Accuracy Estimate 1.089 (lower is better)

Circle Segment 5

Duration 14.64 s, Accuracy Estimate 1.079 (lower is better)

Circle Segment 6

Duration 12.12 s, Accuracy Estimate 1.085 (lower is better)

Circle Segment 7

Duration 11.72 s, Accuracy Estimate 1.268 (lower is better)

Circle Segment 8

Duration 10.44 s, Accuracy Estimate 1.014 (lower is better)

Circle Segment 9

Duration 9.72 s, Accuracy Estimate 1.169 (lower is better)

Circle Segment 10

Duration 8.56 s, Accuracy Estimate 2.348 (lower is better)

Spiral

numSpirals 10
timePerSpiralMean 28.492
timePerSpiralCoV 0.162214
timePerSpiralSlope -0.0470435
meanError 1.45645
tremorFreq 7.12891
tremorRelPower 24.4199
tremorGyroAmpMean 0.0222296
tremorGyroAmpSlope 0.00145167
tremorGyroAmpCoV 0.368529
tremorCoordAmpMean 0.0335141
tremorCoordAmpSlope 0.00122831
tremorCoordAmpCoV 0.261053
tremorAccAmpMean 0.0217978
tremorAccAmpSlope 0.000920218
tremorAccAmpCoV 0.319906
tremorPcRelVar 0.61031
tremorPcX 0.379314
tremorPcY 0.925268

Spiral Segment 1

Duration 35.16 s, Accuracy Estimate 1.469 (lower is better)

Spiral Segment 2

Duration 35.96 s, Accuracy Estimate 1.457 (lower is better)

Spiral Segment 3

Duration 26.44 s, Accuracy Estimate 1.437 (lower is better)

Spiral Segment 4

Duration 31.16 s, Accuracy Estimate 1.512 (lower is better)

Spiral Segment 5

Duration 29.52 s, Accuracy Estimate 1.389 (lower is better)

Spiral Segment 6

Duration 29.0 s, Accuracy Estimate 1.46 (lower is better)

Spiral Segment 7

Duration 27.2 s, Accuracy Estimate 1.377 (lower is better)

Spiral Segment 8

Duration 24.56 s, Accuracy Estimate 1.322 (lower is better)

Spiral Segment 9

Duration 22.24 s, Accuracy Estimate 1.427 (lower is better)

Spiral Segment 10

Duration 23.68 s, Accuracy Estimate 1.715 (lower is better)

Elel

eDurationMean 0.455139
eDurationStd 0.108163
eDurationStdnorm 0.237649
eDurationMedian 0.4325
eDurationQuartdelta 0.0925
eDurationQuartdeltanorm 0.213873
eDurationKurt 5.27386
eDurationTrenddiff -0.0575
eDurationTrendratio 0.877005
eWidthMean 4.082
eWidthStd 1.35229
eWidthStdnorm 0.33128
eWidthMedian 3.978
eWidthQuartdelta 1.8135
eWidthQuartdeltanorm 0.455882
eWidthKurt 2.7839
eWidthTrenddiff -1.1115
eWidthTrendratio 0.7625
eHeightMean 11.2353
eHeightStd 1.71419
eHeightStdnorm 0.152572
eHeightMedian 11.7
eHeightQuartdelta 2.106
eHeightQuartdeltanorm 0.18
eHeightKurt 2.89476
eHeightTrenddiff -0.2925
eHeightTrendratio 0.975124
eAspectMean 0.363525
eAspectStd 0.109883
eAspectStdnorm 0.302272
eAspectMedian 0.340451
eAspectQuartdelta 0.125753
eAspectQuartdeltanorm 0.369371
eAspectKurt 3.30988
eAspectTrenddiff -0.0167048
eAspectTrendratio 0.95172
eSlantMean -0.0370409
eSlantStd 0.140054
eSlantStdnorm -3.78107
eSlantMedian -0.0373832
eSlantQuartdelta 0.166525
eSlantQuartdeltanorm -4.45455
eSlantKurt 2.68922
eSlantTrenddiff 0.0140874
eRtopMean 0.761012
eRtopStd 0.139788
eRtopStdnorm 0.183687
eRtopMedian 0.747093
eRtopQuartdelta 0.163673
eRtopQuartdeltanorm 0.21908
eRtopKurt 4.55687
eRtopTrenddiff -0.0141186
eRbotMean 0.949231
eRbotStd 0.354659
eRbotStdnorm 0.373627
eRbotMedian 0.899259
eRbotQuartdelta 0.492586
eRbotQuartdeltanorm 0.547769
eRbotKurt 2.39256
eRbotTrenddiff 0.0117168
eRrightMean 0.884747
eRrightStd 0.0796127
eRrightStdnorm 0.0899835
eRrightMedian 0.906879
eRrightQuartdelta 0.0710811
eRrightQuartdeltanorm 0.0783799
eRrightKurt 6.10033
eRrightTrenddiff -0.0276975
eRleftMean 0.444667
eRleftStd 0.131951
eRleftStdnorm 0.296742
eRleftMedian 0.46061
eRleftQuartdelta 0.187114
eRleftQuartdeltanorm 0.40623
eRleftKurt 2.62557
eRleftTrenddiff 0.064495
lDurationMean 0.572179
lDurationStd 0.11202
lDurationStdnorm 0.195777
lDurationMedian 0.545
lDurationQuartdelta 0.11375
lDurationQuartdeltanorm 0.208716
lDurationKurt 6.07695
lDurationTrenddiff -0.05
lDurationTrendratio 0.911504
lWidthMean 8.079
lWidthStd 1.93817
lWidthStdnorm 0.239903
lWidthMedian 7.956
lWidthQuartdelta 2.36925
lWidthQuartdeltanorm 0.297794
lWidthKurt 2.45064
lWidthTrenddiff 1.872
lWidthTrendratio 1.27119
lHeightMean 24.195
lHeightStd 2.78587
lHeightStdnorm 0.115142
lHeightMedian 24.336
lHeightQuartdelta 3.3345
lHeightQuartdeltanorm 0.137019
lHeightKurt 3.16389
lHeightTrenddiff 2.457
lHeightTrendratio 1.1066
lAspectMean 0.33449
lAspectStd 0.07179
lAspectStdnorm 0.214626
lAspectMedian 0.334862
lAspectQuartdelta 0.0899348
lAspectQuartdeltanorm 0.268573
lAspectKurt 2.97371
lAspectTrenddiff 0.051569
lAspectTrendratio 1.17823
lSlantMean 0.0899048
lSlantStd 0.0909649
lSlantStdnorm 1.01179
lSlantMedian 0.103734
lSlantQuartdelta 0.123862
lSlantQuartdeltanorm 1.19403
lSlantKurt 3.28641
lSlantTrenddiff 0.101773
lRtopMean 0.863917
lRtopStd 0.0770668
lRtopStdnorm 0.0892063
lRtopMedian 0.86747
lRtopQuartdelta 0.102341
lRtopQuartdeltanorm 0.117977
lRtopKurt 3.44272
lRtopTrenddiff 0.0148541
lRbotMean 0.627282
lRbotStd 0.241883
lRbotStdnorm 0.385605
lRbotMedian 0.595506
lRbotQuartdelta 0.28375
lRbotQuartdeltanorm 0.476487
lRbotKurt 6.03806
lRbotTrenddiff -0.248159
lRrightMean 0.948992
lRrightStd 0.0304288
lRrightStdnorm 0.0320644
lRrightMedian 0.949749
lRrightQuartdelta 0.0378926
lRrightQuartdeltanorm 0.0398975
lRrightKurt 3.56475
lRrightTrenddiff 0.0245272
lRleftMean 0.283176
lRleftStd 0.110989
lRleftStdnorm 0.391945
lRleftMedian 0.255435
lRleftQuartdelta 0.0853105
lRleftQuartdeltanorm 0.333982
lRleftKurt 8.51482
lRleftTrenddiff -0.00441896

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

Elel Segment 9

Elel Segment 10

FITTS Short Modified

meanTouchScore 1
sumTouchScores 1
meanMovementTime nan
numTouches 1
undershootPercentage 0
overshootPercentage 0

fitts_short data not in signals file.

FITTS Long Modified

meanTouchScore 0.906239
sumTouchScores 15.4061
meanMovementTime 1.13094
numTouches 17
undershootPercentage 0
overshootPercentage 17.6471

fitts_long data not in signals file.

ZigZag

numZigzags 5
timePerZigzagMean 24.856
timePerZigzagCoV 0.164542
timePerZigzagSlope -0.100257
meanError 1.98895
tremorFreq 6.93359
tremorRelPower 22.1617
tremorGyroAmpMean 0.0282135
tremorGyroAmpSlope 0.00263993
tremorGyroAmpCoV 0.38002
tremorCoordAmpMean 0.0510639
tremorCoordAmpSlope 0.00240966
tremorCoordAmpCoV 0.319988
tremorAccAmpMean 0.0370513
tremorAccAmpSlope 0.00172669
tremorAccAmpCoV 0.353081
tremorPcRelVar 0.684618
tremorPcX -0.507545
tremorPcY 0.861625

ZigZag Segment 1

Duration 30.44 s, Accuracy Estimate 1.937 (lower is better)

ZigZag Segment 2

Duration 26.72 s, Accuracy Estimate 1.973 (lower is better)

ZigZag Segment 3

Duration 25.4 s, Accuracy Estimate 1.987 (lower is better)

ZigZag Segment 4

Duration 20.76 s, Accuracy Estimate 1.928 (lower is better)

ZigZag Segment 5

Duration 20.96 s, Accuracy Estimate 2.12 (lower is better)

ZigZag Offset

numZigzags 5
timePerZigzagMean 24.6
timePerZigzagCoV 0.157396
timePerZigzagSlope -0.0653659
zigzagHeightMean 88.9112
zigzagHeightCoV 0.0537491
zigzagHeightSlope 0.0256997
meanError 0.0473874
tremorFreq 7.42188
tremorRelPower 26.1057
tremorGyroAmpMean 0.0394841
tremorGyroAmpSlope 0.0034474
tremorGyroAmpCoV 0.512041
tremorCoordAmpMean 0.0595218
tremorCoordAmpSlope 0.0039096
tremorCoordAmpCoV 0.43761
tremorAccAmpMean 0.042354
tremorAccAmpSlope 0.00507506
tremorAccAmpCoV 0.477169
tremorPcRelVar 0.793817
tremorPcX -0.534904
tremorPcY 0.844913

ZigZag Offset Segment 1

Duration 25.44 s, Accuracy Estimate 0.059 (lower is better)

ZigZag Offset Segment 2

Duration 26.96 s, Accuracy Estimate 0.032 (lower is better)

ZigZag Offset Segment 3

Duration 29.32 s, Accuracy Estimate 0.032 (lower is better)

ZigZag Offset Segment 4

Duration 20.8 s, Accuracy Estimate 0.045 (lower is better)

ZigZag Offset Segment 5

Duration 20.48 s, Accuracy Estimate 0.069 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘NOT PD’, ‘HiSpec_score’: 0.77}
RanFor {‘RanFor_class’: ‘PD’, ‘RanFor_score’: 0.73}
BM_May22 {‘BM_May22_class’: ‘PD’, ‘BM_May22_score’: 0.7233692482583249}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Patient’, ‘BM_HC_Sep22_score’: 0.9060019251935223}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘PD’, ‘BM_PD_Sep22_score’: 0.847788404401072}